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and monkey and low predicted clearance in human
InChi: InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H
35 days) addition from day 0 significantly increases myocardial differentiation and results in a significantly increased percentage of CBs with beating cardiomyocytes
Oral administration of Nutlin-3 at 200 mg/kg twice daily for 3 weeks significantly inhibits the tumor growth of SJAS-1 xenografts by 90%
866924-39-2
INCB3344 - CAS# 1262238-11-8 10368 and monkey and low predictedINCB3344 is a potent and selective antagonist of CCR2 receptor with IC(50) values of 5. 1 nM (hCCR2) and 9. 5 nM (mCCR2) in binding antagonism and 3. 8 nM (hCCR2) and 7. 8 nM (mCCR2) in antagonism of chemotaxis activity. INCB3344 exhibited >100 fold selectivity over other homologous chemokine receptors, a free fraction of 24% in human serum and 15% in mouse serum, and an oral bioavailability of 47% in mice, suitable as a tool compound for target
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