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also known as ACT-293987 and NS-304
It binds to BRPF1B with a KD of 31 nM (ITC)
Chemical Name: 4-(hydroxymethyl)phenyl beta-D-glucopyranoside
Smiles: CCNC(=O)NS(=O)(=O)C1SC(CC(C)C)=CC=1C1C=CC(CN2C(=NC(OC)=C2C=O)C2C=CC=CC=2)=CC=1
InChi: InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12
AMG 517 Size:Solid 10 mg also known as ACT-293987 andAMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1. The transient receptor potential vanilloid 1 (TRPV1) channel plays a suppressive role in the systemic inflammatory response syndrome (SIRS) by inhibiting production of tumor necrosis factor (TNF) and possibly by other mechanisms. TRPV1 antagonists, widely viewed as new generation painkillers, may decrease the resistance of older
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