Emavusertib - CAS# 1801344-14-8 ericin B InChi: InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4

InChi: InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4

thereby inhibiting DNA replication and inducing apoptosis

is a potent and selective allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor with IC50 ~ 230 nM

74 with vehicle) at high glucose concentration (12

chemokine receptor CXCR4

Emavusertib - CAS# 1801344-14-8 ericin B InChi: InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4Emavusertib, also known as CA 4948 is a potent IRAK4 FLT3 inhibitor with anti tumor activity. CA 4948 demonstrated good cellular activity in ABC DLBCL and AML cell lines. CA 4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with