ANI-7 EG1-COOH induces apoptosis and pro-death autophagy

induces apoptosis and pro-death autophagy in A549 lung cancer cells

InChi: InChI=1S/C15H20N4O3/c1-4-18(5-2)12-7-6-11(9-13(12)19(21)22)15-10(3)8-14(20)16-17-15/h6-7

(2012) Nat Med

InChiKey: YKJYKKNCCRKFSL-RDBSUJKOSA-N

CAS Number: 775351-61-6

ANI-7 EG1-COOH induces apoptosis and pro-death autophagyANI 7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI 7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF 7 breast cancer cells with a GI50 of 0. 56 M. ANI 7 induces CYP1 metabolizing mono oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S phase cell cycle arrest, and cell death in sensitive breast cancer cell lines. Product